The firmware flash button (labeled Q-Flash Plus) is not needed when performing UEFI firmware updates via the System76 Firmware Manager. Use of this button is not recommended.
Thelio Mega R4-N3 ships with an external Gigabyte wireless antenna module. This module should be plugged into the wireless antenna port (labeled Wifi on the machine) before WiFi or Bluetooth are used.
The module can connect in either direction (there's no pin that must be on the left or right).
The DisplayPort pass-through input (labeled DP IN on the machine) provides an input to pass a DisplayPort signal from a graphics card into the top USB4 (Type-C) port.
Connect a GPU's DisplayPort output to the DisplayPort pass-through input (DP IN) port.
Then, connect a USB-C display (or docking station) to the top USB4 (Type-C) port to view the DisplayPort signal.
The top USB4 (Type-C) port is additionally labeled DP on the machine to signify that it's the pass-through output port.